1.Do not take phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects. 2.Phenylpropanolamine may also interact with the following medicines: *furazolidone (Furoxone); *guanethidine (Ismelin); *indomethacin (Indocin); *methyldopa (Aldomet); *bromocriptine (Parlodel); *caffeine in cola, tea, coffee, chocolate, and other products; *theophylline (Theo-Dur, Theochron, Theolair, others); *tricyclic antidepressants such as amitriptyline (Elavil, Endep), doxepin (Sinequan), and nortriptyline (Pamelor); *other commonly used tricyclic antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), protriptyline (Vivactil), and trimipramine (Surmontil); *phenothiazines such as chlorpromazine (Thorazine), thioridazine (Mellaril), and prochlorperazine (Compazine);and *other commonly used phenothiazines, including fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), and trifluoperazine (Stelazine). 3.Drugs other than those listed here may also interact with phenylpropanolamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

1.If you experience any of the following serious side effects from this medication, stop taking phenylpropanolamine and seek emergency medical attention: *an allergic reaction (difficulty breathing;closing of your throat;swelling of your lips, tongue, or face;or hives); *seizures; *unusual behavior or hallucinations;or *an irregular or fast heartbeat. 2.Other, less serious side effects may be more likely to occur. Continue to take phenylpropanolamine and talk to your doctor if you experience *dizziness, lightheadedness, or drowsiness; *headache; *insomnia; *anxiety; *tremor (shaking) or restlessness; *nausea or vomiting;or *sweating. 3.Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

1.Do not take phenylpropanolamine for longer than 7 days if your condition does not improve or if your symptoms are accompanied by a high fever. 2.Do not take more of this medication than is recommended on the package or by your doctor. 3.Use caution when driving, operating machinery, or performing other hazardous activities. Phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. If Miss a Dose: 1.Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication. Contraindications: 1.Do not take phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects. 2.Before taking this medication, tell your doctor if you have *high blood pressure; *any type of heart disease, hardening of the arteries, or irregular heartbeat; *thyroid problems; *diabetes; *glaucoma or increased pressure in your eye; *an enlarged prostate or difficulty urinating;or *liver or kidney disease. 3.You may not be able to take phenylpropanolamine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. 4.It is not known whether phenylpropanolamine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. 5.Infants are especially sensitive to the effects of phenylpropanolamine. Do not take this drug if you are breast-feeding a baby. 6.If you are over 60 years of age, you may be more likely to experience side effects from phenylpropanolamine. You may require a lower dose of this medication. Using a short-acting formulation of phenylpropanolamine (not a long-acting or a controlled-release formulation) may be safer if you are over 60 years of age. Special Concerns: 1.Use caution when driving, operating machinery, or performing other hazardous activities. Phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. 2.Never take this medication in larger doses or more often than is recommended. Too much phenylpropanolamine could be very harmful.